The applicability of Artificial Intelligence to trademark disputes in Nigeria is a matter of growing interest. Over the years, the trademark resolution process of infringement disputes in Nigeria is traditional, orthodox, and complex, with its multifaceted procedure that involves several steps, including human efforts that goes at snail pace. As a result of the emergence of artificial intelligent (AI) in our daily life and society, it is lucid that AI have not only outsmart the human intellect, but has become the world leading helper and now incorporated into basically all fields of life, including Medicine, Art, Engineering, and Law. This paper seeks to examine the Nigerian trademark dispute resolution framework, identify specific AI technologies utilized in resolving similar disputes and its cost-effectiveness. It further seeks to compare few jurisdictions that have integrated AI into their resolution processes. The methodology adopted is doctrinal method of legal research, having both primary and secondary data handy. Some challenges were observed as detrimental to incorporating AI to Trademark dispute resolutions in Nigeria ranging from not up-to-date legal framework, absence of quality data, cost, management and maintenance implications of the AI systems. It is recommended that in as much as integrating AI as problem solving technique has the potential to enhance a consistent, effective and efficient trademark disputes resolution mechanism, a successful implementation requires much more, which includes adequate training of man power, proper funding and creation of constant awareness of its presence to concerned stakeholders and the Nigerian public.