This study assesses the impact of global environmental changes on logistics and transportation efficiency within the manufacturing sector, using Blue Skies Ghana as a case study. A quantitative research design was employed, utilizing a descriptive survey approach to collect structured numerical data from 50 logistics and transportation staff, including supply chain managers, fleet operators, and warehousing personnel. Data were gathered through a structured questionnaire, focusing on key metrics such as delivery timelines, cost management, and disruption frequency, using a 5-point Likert scale. The questionnaire was distributed online to ensure convenience, accuracy, and anonymity. Data analysis was conducted using SPSS, with descriptive statistics summarizing trends and patterns, while inferential statistics, including correlation and regression analyses, examined the relationship between global environmental changes and logistics efficiency. Ethical considerations were strictly adhered to, ensuring informed consent and data confidentiality. The findings reveal that global environmental changes, such as fluctuating fuel prices, extreme weather events, and rising temperatures, significantly impact logistics efficiency at Blue Skies Ghana. Key challenges include increased transportation delays, higher fuel consumption, and extended delivery times, which are closely linked to climatic factors like rainfall and temperature. Despite these challenges, Blue Skies Ghana has implemented proactive sustainability measures, such as renewable energy adoption, water conservation, and employee training, to mitigate environmental impacts and enhance operational resilience. The study recommends further investment in environmentally friendly technologies, such as solar energy and electric vehicles, to reduce reliance on fossil fuels and lower carbon emissions. Additionally, it suggests improving supply chain resilience through diversification of transportation routes, strategic warehouse placement, and advanced data analytics for weather forecasting and operational optimization. Continuous employee training on sustainability practices is also emphasized to foster a culture of environmental responsibility and operational efficiency.