Digital transformation is becoming an inevitable trend, having a far-reaching impact on socio-economic development in Vietnam in general and Ca Mau province in particular. With more than 5,000 enterprises, of which 98% are small and medium enterprises, Ca Mau has advantages in marine economy, fisheries, and renewable energy, and faces many challenges in infrastructure, human resources, and investment capital for digital transformation. Recently, the provincial government has issued action plans, coordinated with major technology corporations, and encouraged enterprises to apply e-commerce, management software, and traceability systems. However, the digital divide between large and small enterprises, limitations in access to finance, and the fear of change still exist. The article focuses on analyzing the current situation, challenges, and issues in Ca Mau's digital transformation process.