Digital nomadism and remote-first startups have emerged as significant trends redefining modern entrepreneurship. Fueled by technological advancement, globalization, and shifting workplace values, these phenomena enable a lifestyle where work is no longer confined to specific geographies. This paper offers a comprehensive review of literature on digital nomads and remote-first businesses, analyzing how these developments have transformed entrepreneurial behavior, team dynamics, legal frameworks, and socio-economic interactions. Through systematic analysis, the study explores the operational, financial, cultural, and psychological impacts of location-independent entrepreneurship. Key implications for policy, startup ecosystems, and global workforce mobility are discussed, with directions for future research in digital entrepreneurship.