This article aims to explore the multifaceted nature of poverty in Africa and the African Diaspora, emphasizing the systemic barriers that perpetuate inequality and offering practical solutions for poverty alleviation. It aims to highlight the intersectionality of poverty, addressing its economic, social, and environmental dimensions in both regions, with a focus on actionable strategies to improve quality of life and promote sustainable development. Poverty in Africa and the African Diaspora remains pervasive, despite various development initiatives. In Africa, challenges such as poor governance, climate change, and limited access to education and healthcare continue to exacerbate poverty. Similarly, historical legacies like colonialism, systemic racism, and unequal access to resources in the Diaspora perpetuate social and economic disparities. The persistence of these conditions calls for comprehensive strategies to effectively tackle poverty and enhance the livelihoods of marginalized populations. The article contributes to the discourse on poverty reduction by examining the unique challenges faced by both Africa and the African Diaspora. It provides a comprehensive framework for poverty alleviation, emphasizing gender equality, climate resilience, economic inclusion, education access, and social protection systems. The article offers practical recommendations, grounded in evidence from both regions, to guide policymakers and development practitioners in implementing sustainable and inclusive poverty reduction strategies. This article employs a systematic literature review methodology, synthesizing recent research and historical data on poverty in Africa and the African Diaspora. A range of academic, governmental, and international organization reports have been analyzed to draw a comprehensive understanding of the issue. The review considers both qualitative and quantitative studies, allowing for a nuanced exploration of the social, economic, and political factors contributing to poverty in these regions. Addressing poverty in Africa and the African Diaspora requires a multifaceted, coordinated approach that integrates social protection, sustainable development, gender empowerment, and inclusive economic growth. The findings suggest that while progress has been made, more concerted efforts are needed to build resilient communities and ensure equitable access to resources. The article concludes with a call for stronger political will, better governance, and deeper engagement of the African Diaspora in development initiatives to create lasting poverty alleviation solutions.