The study investigated strategic innovation and sustainable economic performance of manufacturing sector in Rivers State. It adopted the correlational research design and operationalized the innovation into the variables of product innovation, technological innovation, and social innovation with sustainable economic performance as the dependent variable. The population of the study was 150 which consisted of staff of manufacturing companies operating in Rivers State. The sample size of 150 was used adopting the census sampling technique in which the entire population was used. A questionnaire instrument tagged, Strategic Innovation and Sustainable Economic Performance (SISEP) was used and calibrated into modified Likert scale of Very High Extent (4), High Extent (3), Low Extent (2), Very Low Extent (1). The three research questions were answered using Mean and Standard Deviation at mean criterion of 2.5, while the null hypotheses were tested using Pearson Product Correlation Coefficient (PPMC) at .05 significance level. The findings of the study showed that the variables of strategic innovation significantly relate to sustainable economic performance in manufacturing companies in Rivers State. The study concluded that if marketing innovative measures of product design or innovation, appropriate technology and social innovation are applied sustainably, will lead to improved economic performance of manufacturing companies in Rivers State. It recommended among others that, manufacturing companies in Rivers State should from time-to-time train and retrain their staff on modern technological innovations to improve on their economic performance.