This study examines the marginalization of the Southern Globe in the historical, cultural and epistemological context within the framework of the concept of subaltern theory and epistemic injustice. In the study, first of all, Gayatri Chakravorty Spivak said, "Can Subaltern speaks?" Based on the question, silence and invisibility attributed to the Southern Globe in global information production were analyzed. The concept of epistemic injustice, the structural foundations of the knowledge between the South-North has been put forward by discussing the witness injustice defined by Miranda Fricker and the forms of Hermeneutic injustice. The permanent effects of colonial heritage on information policies; It is supported by cases how local information systems, cultural narratives and social experiences are systematically excluded in the fields of international academy and policy. The study was embodied through the epistemological marginalization of Latin American indigenous peoples, the postcolonial information construction processes in Africa, and the invisibility problems experienced by the Pacific Islands in environmental information production. The findings show that the Southern Globe is not only economic or political, but also in an epistemological inequality network. As a result, it is emphasized that southern epistemology should be made more visible and effective in the circulation of institutional academy and global knowledge in order to achieve epistemic justice. In this context, it is recommended to establish solidarity -based information networks, to protect local information systems and to encourage multilingual, multicultural academic production models