This paper explores the intricate dynamics of U.S.-Iran relations through the lenses of think tanks, economic factors, and the political landscape within Iran. It examines how various think tanks in the United States influence policy decisions regarding Iran, shaping public discourse and government strategies. The analysis highlights the impact of economic sanctions and trade relations on bilateral ties, emphasizing how economic considerations often intersect with geopolitical interests. Furthermore, the paper delves into the internal political structures of Iran, assessing how domestic politics and leadership changes affect Iran's foreign policy and its interactions with the U.S. By synthesizing these elements, the study aims to provide a comprehensive understanding of the multifaceted relationship between the two nations and the implications for future diplomatic efforts.