This study was to determine users’ perception of the factors hindering book availability, accessibility and utilization in University of Cross River State Library, Calabar. A survey research design was used while questionnaire was administered to 220 library users randomly selected from 25,347 registered users of the University library, 203 questionnaires were returned, 16 of the returned questionnaires were rejected because they were not completely filled. A total of 187 questionnaires were used for the analysis. The data was analyzed using descriptive statistics (mean score). The findings revealed that insufficient subvention to libraries for purchase of information materials, general books scarcity and cost of library materials were the major factors hindering book availability, accessibility, and utilization. The results also show that non-availability of the required documents within the users time constraint and lack of knowledge of information resources available in the libraries which could satisfy the users’ information needs were the foremost factors that inhibit book accessibility and utilization, while review of closed access policy in libraries and strengthening national initiatives on book development were seen as possible strategies for the improvement of book availability for enhanced users’ satisfaction in University of Cross River State Library, Calabar. The study recommends that: Annual budget allocation to the university library should be improved. A comprehensive tools and retrieval devices should be provided in order to direct users to specific locations of information resources in the library. The indigenous commercial publishers and authors should be encourage to engage on scholarly publication.